Endocrine Abstracts

Objective: Evaluation of aftercare, medical therapy and remission rate in Cushing’s disease (CD) and acromegaly (AC).Methods: Of 58 CD and 83 AC patients operated over 10 years were carefully evaluated. The patients received a disease-related questionnaire and were invited for a follow-up at the outpatient clinic of the Department of Neurosurgery. 33 CD and 52 AC patients returned the questionnaire, 25 CD and 37 AC patients participated personally. ...

Objective: Cushing’s disease (CD) and acromegaly (AC) are associated with psychological and psychiatric problems. Both pathologies cause a severe impairment in quality of life (QoL) that can persist even if biochemical remission and cure are achieved. The aim of the study was to investigate the influence of the current disease status (remission vs. no remission) on neurocognitive function and QoL in treated CD and AC patients. The second objective was to determine predict...

Objective: The aim of the study was to analyze the time-to-diagnosis interval in patients with Cushing’s disease (CD) and acromegaly (AC), to assess factors that promote early disease detection and to investigate the medical fields diagnosing the pathologies.Design: Case-record retrospective study.Patients: CD and 52 AC patients operated between June 1998 and December 2007.Measurements: All patients rece...

Objective: It is still unknown how pituitary adenomas grow over years and whether growth kinetics follow a distinct growth model. Definition of adenoma growth kinetics would substantially enhance knowledge of biological behaviour. The objective of this study was to define a growth model for non-functioning pituitary adenomas.Methods: Fifteen patients who had five or more serial high-quality examinations with magnetic resonance images or computerized tomo...